Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease
Carlos W. Gantner, Isabelle R. de Luzy, Jessica A. Kauhausen, Niamh Moriarty, Jonathan C. Niclis, Christopher R. Bye, Vanessa Penna, Cameron J. Hunt, Charlotte M. Ermine, Colin W. Pouton, Deniz Kirik, Lachlan H. Thompson, Clare L. Parish
Topics & Concepts
Glial cell line-derived neurotrophic factorNeurotrophic factorsBiologyInduced pluripotent stem cellDopaminergicTransplantationNeuroscienceParkinson's diseaseMAPK/ERK pathwayProto-Oncogene Proteins c-retNeurotrophinStem cellCell biologyGDNF family of ligandsEmbryonic stem cellDopamineKinaseDiseaseInternal medicineMedicineReceptorBiochemistryGenePluripotent Stem Cells ResearchNerve injury and regenerationCRISPR and Genetic Engineering