Enhanced nose-to-brain delivery of siRNA using hyaluronan-enveloped nanomicelles for glioma therapy
Yuling Yang, Xueyan Zhang, Siwen Wu, Rui Zhang, Bailing Zhou, Xiaoyu Zhang, Lin Tang, Yaomei Tian, Ke Men, Li Yang
Topics & Concepts
Nasal administrationGliomaCD44In vivoHyaluronic acidPharmacologyMedicineSmall interfering RNACancer researchCell-penetrating peptideBlood–brain barrierCytotoxicityDrug deliveryIn vitroChemistryPathologyCentral nervous systemCellBiologyInternal medicineTransfectionBiochemistryAnatomyBiotechnologyGeneOrganic chemistryRNA Interference and Gene DeliveryAdvanced Drug Delivery SystemsSupramolecular Self-Assembly in Materials