A self-amplified ferroptosis nanoagent that inhibits the tumor upstream glutathione synthesis to reverse cancer chemoresistance
Chuang Yang, Zheng Chen, Min Wei, Shen Hu, Mengyuan Cai, Nan Wang, Yunan Guan, Fangyuan Li, Qiang Ding, Daishun Ling
Topics & Concepts
GlutathioneIntracellularCancer cellGPX4DoxorubicinIn vivoChemistryCancer researchApoptosisCancerCell biologyBiologyBiochemistryChemotherapyGlutathione peroxidaseEnzymeGeneticsBiotechnologyFerroptosis and cancer prognosisEpigenetics and DNA MethylationNanoplatforms for cancer theranostics