Zn doped iron oxide nanoparticles with high magnetization and photothermal efficiency for cancer treatment
Georgios Kasparis, Anouchka Plan Sangnier, Lilin Wang, Christoforos Efstathiou, Alec P. LaGrow, Ανδρέας Σεργίδης, Claire Wilhelm, Nguyễn Thị Kim Thanh
Abstract
). Magnetothermal conversion was minimally hindered in the cellular confinement whilst photothermal efficiency remained unchanged. Photothermia treatment alone achieved 100% cell death after 10 min of treatment compared to only 30% cell death achieved with magnetothermia at clinically relevant settings for each at their best performing concentration. Altogether, these results suggest that the biocompatible and superparamagnetic zinc ferrite NPs could be a next biomaterial of choice for photo-hyperthermia, which could outperform current iron oxide NPs for magnetic hyperthermia.
Topics & Concepts
Materials sciencePhotothermal therapyMagnetizationNanoparticleDopingIonCrystal structureOxideIron oxide nanoparticlesChemical engineeringNanotechnologyOptoelectronicsMetallurgyCrystallographyChemistryMagnetic fieldOrganic chemistryPhysicsQuantum mechanicsEngineeringIron oxide chemistry and applicationsNanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic Nanoparticles