SEPHS1 attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway
Tao Hu, Zhongming Shi, Yongjin Sun, Feng Hu, Yuluo Rong, Jia Wang, Liang Wang, Wenbin Xu, Feng Zhang, Wenzhi Zhang
Abstract
Selenophosphate synthetase 1 (SEPHS1) deficiency leads to an increase in reactive oxygen species levels and in the subsequent activation of the Hippo-Yap/Taz signaling pathway. In the rat model of intervertebral disc degeneration (IVDD), overexpression of SEPHS1 and inhibition of Hippo-YAP/Taz mitigated the progression of disc degeneration indicating the involvement of SEPHS1 in IVDD. SEPHS1 is a promising therapeutic target for IVDD.
Topics & Concepts
SenescenceHippo signaling pathwayReactive oxygen speciesOxidative stressCell biologyBiologyIn vivoCellCancer researchSignal transductionEndocrinologyBiochemistryGeneticsSpine and Intervertebral Disc Pathology