Fluorogenic iminosydnones: bioorthogonal tools for double turn-on click-and-release reactions
Margaux Riomet, Karine Porte, Anne Wijkhuisen, Davide Audisio, Frédéric Taran
Abstract
In this article, we report the synthesis and use of iminosydnone-based profluorophores as bioorthogonal cleavable linkers for imaging applications. These linkers react with cycloalkynes via subsequent [3+2] cycloaddition and retro Diels-Alder reactions, allowing simultaneous release of two dyes in biological media.
Topics & Concepts
Bioorthogonal chemistryClick chemistryChemistryTurn (biochemistry)FluorescenceCombinatorial chemistryBiophysicsNanotechnologyBiochemistryMaterials scienceBiologyPhysicsQuantum mechanicsClick Chemistry and ApplicationsChemical Synthesis and AnalysisCancer Research and Treatments