Tri-metallic (Au–Pt–Ag) nanofluids: unveiling synergistic anti-malarial, cytotoxic, and antioxidant potentials through experimental and computational approaches
Amit Dubey, Manish Kumar, Aisha Tufail, Abhay Bagul
Abstract
proteins. The high degree of correlation between experimental and computational results confirms the reliability of these nanofluids in targeting malaria. Additionally, ADMET profiling highlighted their optimal pharmacokinetic properties, including efficient intestinal absorption, minimal CNS penetration, and favorable metabolic characteristics. The coherence between computational predictions and experimental observations underscores the robustness of Au-Pt-Ag nanofluids as next-generation therapeutic agents for malaria and oxidative stress-related disorders, paving the way for further preclinical investigations and clinical applications.
Topics & Concepts
NanofluidDensity functional theoryAntioxidantCytotoxic T cellMetalChemistryMaterials scienceComputational chemistryNanotechnologyNanoparticleBiochemistryOrganic chemistryIn vitroComputational Drug Discovery MethodsNanoparticles: synthesis and applicationsFree Radicals and Antioxidants