A Novel Enterococcus faecalis Heme Transport Regulator (FhtR) Senses Host Heme To Control Its Intracellular Homeostasis
Vincent Saillant, Damien Lipuma, Emeline Ostyn, Laetitia Joubert, Alain Boussac, Hugo Guerin, Géraldine Brandelet, Pascal Arnoux, Delphine Lechardeur
Abstract
Enterococcus faecalis , a normal and harmless colonizer of the human intestinal flora can cause severe infectious diseases in immunocompromised patients, particularly those that have been heavily treated with antibiotics. Therefore, it is important to understand the factors that promote its resistance and its virulence. E. faecalis , which cannot synthesize heme, an essential but toxic metabolite, needs to scavenge this molecule from the host to respire and fight stress generated by oxidants.
Topics & Concepts
Enterococcus faecalisHemeVirulenceMicrobiologyRegulatorIntracellularAntibioticsMetaboliteBacteriaBiologyHomeostasisChemistryBiochemistryCell biologyStaphylococcus aureusEnzymeGeneGeneticsClostridium difficile and Clostridium perfringens researchAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in Bacteria