Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition
Jacob J. Swidorski, Susan Jenkins, Umesh Hanumegowda, Dawn D. Parker, Brett R. Beno, Tricia Protack, Alicia Ng, Anuradha Gupta, Yoganand Shanmugam, Ira B. Dicker, Mark Krystal, Nicholas A. Meanwell, Alicia Regueiro‐Ren
Topics & Concepts
PharmacophoreChemistryBioisostereSubstituentStereochemistryBenzoic acidContext (archaeology)Carboxylic acidMoietyAlkylPotencyLead compoundCombinatorial chemistryPharmacologyChemical synthesisBiochemistryIn vitroOrganic chemistryBiologyMedicinePaleontologyHIV/AIDS drug development and treatmentHIV Research and TreatmentBiochemical and Molecular Research