An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair
Jiacheng Guo, Zhenzhen Yang, Yongzheng Lu, DU Chunyan, Chang Cao, Bo Wang, Xiao-Ting Yue, Zenglei Zhang, Yanyan Xu, Zhen Qin, Ting‐Ting Huang, Wei Wang, Wei Jiang, Jinying Zhang, Junnan Tang
Abstract
Acute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme with Superoxide Dismutase (SOD) activity cross-link with Zr-based metal-organic framework (ZrMOF) (SOD-ZrMOF) for mitigate ROS-caused injury. In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility. By efficiently scavenging ROS and suppressing oxidative stress, SOD-ZrMOF can protect the function of mitochondria, reduce cell death and alleviate inflammation. More excitingly, long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area, protect cardiac function, promote angiogenesis and inhibit pathological myocardial remodeling. Therefore, SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI.