Cancer-associated fibroblast-derived extracellular vesicles loaded with GLUT1 inhibitor synergize anti-PD-L1 to suppress tumor growth via degrading matrix stiffness and remodeling tumor microenvironment
Yali Wu, Wenjuan Chen, Jingjing Deng, Xingyu Zhou, Jiangbin Chen, Zimo Yang, Xinghui Cao, Jiatong Liu, Qi Tan, En Zhou, Minglei Li, Mengfei Guo, Yang Jin
Topics & Concepts
Tumor microenvironmentGLUT1Cancer researchImmunotherapyExtracellular matrixCancer immunotherapyStromal cellCancerCancer-Associated FibroblastsCancer cellImmune systemTumor progressionGlucose transporterBiologyMedicineChemistryImmunologyCell biologyInternal medicineInsulinExtracellular vesicles in diseaseImmune cells in cancerNanoplatforms for cancer theranostics