Effects of norepinephrine on microglial neuroinflammation and neuropathic pain
Helin Zou, Juan Li, Junli Zhou, Xi Yi, Song Cao
Abstract
Norepinephrine (NE) is an important neurotransmitter in the central nervous system. NE is released from locus coeruleus neurons and is involved in a variety of physiological and pathological processes. Neuroinflammation is a common manifestation of many kinds of neurological diseases. The activation of microglia directly affects the status of neuroinflammation. Several kinds of adrenergic receptors, which anchor on microglia and can be regulated by NE, affect the activation of microglia and neuroinflammation. NE influences chronic pain, anxiety, and depression by regulating the activation of microglia.
Topics & Concepts
NeuroinflammationLocus coeruleusMicrogliaNorepinephrineNeuroscienceNeuropathic painMedicineCentral nervous systemPsychologyInternal medicineInflammationDopamineNeuroinflammation and Neurodegeneration MechanismsPain Mechanisms and TreatmentsNeuropeptides and Animal Physiology