The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation
You‐Jin Choi, Geunhye Lee, Sung Ho Yun, Wonseok Lee, Jieun Yu, Sang Kyum Kim, Byung‐Hoon Lee
Topics & Concepts
PI3K/AKT/mTOR pathwayLipid metabolismGlycineSerine hydroxymethyltransferaseSerineDownregulation and upregulationChemistryLipogenesisGene knockdownSteatosisMetabolismBiochemistryBiologyCell biologySignal transductionAmino acidPhosphorylationEndocrinologyGeneLiver Disease Diagnosis and TreatmentFolate and B Vitamins ResearchRNA modifications and cancer