Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition
Mohammed M. Amin, Gamal El‐Din A. Abuo‐Rahma, Montaser Sh. A. Shaykoon, Adel A. Marzouk, Mohammed A. S. Abourehab, Roshdy E. Saraya, Mohamed Badr, Ahmed M. Sayed, Eman A. M. Beshr
Topics & Concepts
ChemistryChalconeStaurosporineMTT assayDocking (animal)TubulinApoptosisBiochemistryMicrotubulePharmacologyKinaseStereochemistryCell biologyProtein kinase ABiologyMedicineNursingSynthesis and biological activityClick Chemistry and ApplicationsQuinazolinone synthesis and applications