Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling
Yves Yeboue, Marion Jean, Gilles Subra, Jean Martinez, Frédéric Lamaty, Thomas‐Xavier Métro
Abstract
Peptides were produced in high yields and, if any, very low epimerization, by mechanochemical coupling of peptide fragments containing highly epimerization-prone and/or highly hindered amino acids at C-term. Ball milling was clearly identified as the key element enabling one to obtain such results.
Topics & Concepts
EpimerChemistryBall millPeptideStereochemistryBall (mathematics)Chemical engineeringBiochemistryEngineeringMathematical analysisMathematicsChemical Synthesis and AnalysisBiochemical and Structural CharacterizationSupramolecular Self-Assembly in Materials