Iridium(III)-Catalyzed Tandem Annulation of Pyridine-Substituted Anilines and α-Cl Ketones for Obtaining 2-Arylindoles
Xinfeng Cui, Xin Qiao, Hesong Wang, Guosheng Huang
Abstract
-(2-pyridyl)anilines and commercially available α-Cl ketones through iridium-catalyzed C-H activation and cyclization is reported here. As a complementary approach to the conventional strategies for indole synthesis, the transformation exhibits powerful reactivity, tolerates a large number of functional groups, and proceeds with good to excellent yields under mild conditions, providing a straightforward method to obtain structurally diverse and valuable indole scaffolds. Furthermore, the reaction could be easily scaled up to gram scale.
Topics & Concepts
ChemistryAnnulationIridiumTandemIndole testCombinatorial chemistryCatalysisPyridineReactivity (psychology)Functional groupOrganic chemistryMaterials scienceMedicinePathologyPolymerComposite materialAlternative medicineCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis