Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications
Maryam Sharifiaghdam, Elnaz Shaabani, Zeynab Sharifiaghdam, Herlinde De Keersmaecker, Bart Lucas, Joris Lammens, Hossein Ghanbari, Ladan Teimoori‐Toolabi, Chris Vervaet, Thomas De Beer, Reza Faridi‐Majidi, Stefaan C. De Smedt, Kevin Braeckmans, Juan C. Fraire
Abstract
scratch assay. These results show that irf5-siRNA loaded PEI-LBL-NCs are a promising therapeutic approach to tune macrophage polarization for improved wound healing.
Topics & Concepts
ReprogrammingWound healingPhenotypeMacrophageCell biologyIRF5Cancer researchChemistryImmunologyMedicineCellBiologyGeneIn vitroImmune systemInnate immune systemBiochemistryInterferon regulatory factorsRNA Interference and Gene DeliveryGraphene and Nanomaterials ApplicationsTissue Engineering and Regenerative Medicine