Decade Advance of Isatin in Three‐component Reactions
Shuaijie Zhang, Dayun Huang, Jinjing Wu, Zefeng Wang
Abstract
Abstract Isatin is an important building block in organic synthesis. The electron‐deficient carbonyl in C‐3 site is similar to aldehyde. C‐3 carbonyl is also able to function as the O‐nucleophile. Devise methodologies about three‐component reactions of isatin have been reported in this decade. This review highlights these multicomponent reactions by triggered mechanisms. We hope it will promote future research in this area.
Topics & Concepts
IsatinChemistryAldehydeNucleophileComponent (thermodynamics)Block (permutation group theory)Combinatorial chemistryOrganic chemistryCatalysisMathematicsThermodynamicsPhysicsGeometryMulticomponent Synthesis of HeterocyclesChemical Synthesis and AnalysisSynthesis and biological activity