Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells
Phuong Nguyen, Emmanuel Sunday Okeke, Michael R. Clay, Dalia Haydar, Julie Justice, Carla O’Reilly, Shondra M. Pruett‐Miller, James B. Papizan, Jennifer C. Moore, Sheng Zhou, Robert E. Throm, Giedre Krenciute, Stephen Gottschalk, Christopher DeRenzo
Abstract
and improved antitumor activity in one of four evaluated models. Thus, our study highlights the intricate interplay between CAR hinge/transmembrane and costimulatory domains. Based on our study, we selected CD8α/CD28-CAR T cells expressing 41BBL for early phase clinical testing.
Topics & Concepts
EffectorFunction (biology)Computer scienceMedicineCell biologyImmunologyBiologyCAR-T cell therapy researchImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers