Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector
Tadakimi Tomita, Debanjan Mukhopadhyay, Bing Han, Rama Yakubu, Vincent Tu, Joshua Mayoral, Tatsuki Sugi, Yanfen Ma, Jeroen P. J. Saeij, Louis M. Weiss
Abstract
Toxoplasma gondii is an Apicomplexan that infects a third of humans, causing encephalitis in AIDS patients and intellectual disabilities in congenitally infected patients. We determined that one of the cyst matrix proteins, MAG1, which had been thought to be an innate structural protein, can be secreted into the host cell and suppress the host immune reaction.
Topics & Concepts
SecretionVacuoleCell biologyBiologyEffectorInflammasomeImmune systemCytosolImmunologyCytoplasmInflammationBiochemistryEnzymeToxoplasma gondii Research StudiesHerpesvirus Infections and TreatmentsRabies epidemiology and control