Mechanisms of severe acute intermittent hypoxia-induced phrenic long-term facilitation
Nicole L. Nichols, Gordon S. Mitchell
Abstract
Distinct mechanisms give rise to pLTF induced by moderate and severe AIH. We demonstrate that, unlike moderate AIH, severe AIH-induced pLTF requires EPAC and PI3K/Akt and is marginally constrained by NADPH oxidase activity. Surprisingly, sAIH-induced pLTF requires MEK/ERK activity similar to moderate AIH-induced pLTF and is reduced by PKA inhibition. We suggest sAIH-induced pLTF arises from complex interactions between dominant mechanisms characteristic of moderate versus severe AIH-induced pLTF.
Topics & Concepts
Protein kinase BNADPH oxidaseApocyninMAPK/ERK pathwayReceptorIntermittent hypoxiaPI3K/AKT/mTOR pathwayChemistryProtein kinase APharmacologyBiologySignal transductionInternal medicineKinaseMedicineBiochemistryReactive oxygen speciesObstructive sleep apneaNeuroscience of respiration and sleepNeuroendocrine regulation and behaviorSleep and Wakefulness Research