Redox-responsive polyprodrug nanoparticles for targeted siRNA delivery and synergistic liver cancer therapy
Senlin Li, Phei Er Saw, Chunhao Lin, Yan Nie, Wei Tao, Omid C. Farokhzad, Lei Zhang, Xiaoding Xu
Topics & Concepts
Asialoglycoprotein receptorEthylene glycolGene silencingDoxorubicinCancer researchSystemic administrationGlutathioneApoptosisCancer cellChemistryDrug deliveryGenetic enhancementPharmacologyIn vivoBiophysicsMaterials scienceCancerBiochemistryNanotechnologyBiologyIn vitroChemotherapyBiotechnologyEnzymeGeneticsOrganic chemistryGeneHepatocyteRNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryAdvanced biosensing and bioanalysis techniques