Layered double hydroxide nanosheets: towards ultrasensitive tumor microenvironment responsive synergistic therapy
Yan Liang, Yingjie Wang, Tingting Hu, Xuan Mei, Xiaojie Zhao, Yanyan Bian, Lan Jin, Ruizheng Liang, Xisheng Weng, Min Wei
Abstract
-enhancement. In addition, both in vitro and in vivo therapeutic tests based on Ce6/CoMn-LDH demonstrate a satisfactory anticancer activity with complete cancer cell apoptosis and dramatic tumor elimination. This work provides a new perspective for the design of multifunctional 2D nanosheets towards a fully promoted TME-responsive synergistic therapy, which holds great promise for future clinical diagnosis and treatment.
Topics & Concepts
Tumor microenvironmentPhotodynamic therapyTumor hypoxiaHydroxideGlutathioneIn vivoMaterials scienceCancer researchCancer therapyNanotechnologyBiophysicsChemistryCancerTumor cellsBiochemistryEnzymeRadiation therapyMedicineBiologyBiotechnologyOrganic chemistryInternal medicineNanoplatforms for cancer theranosticsAdvanced Photocatalysis TechniquesAdvanced Nanomaterials in Catalysis