Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project
Marco Mussa, Pedro María Martínez Pérez-Crespo, Luis Eduardo López-Cortés, Pilar Retamar, Adrián Sousa-Dominguez, Ane Josune Goikoetxea-Aguirre, José María Reguera-Iglesias, Eva María León Jiménez, Isabel Fernández-Natal, Carlos Armiñanzas-Castillo, Lucía Boix-Palop, Jordi Cuquet-Pedragosa, Miguel Ángel Morán Rodríguez, Jonathan Fernández-Suárez, Alfonso del Arco, A Jover, Alberto Bahamonde-Carrasco, Fátima Galán‐Sánchez, Juan Manuel Sánchez Calvo, Alejandro Smithson-Amat, David Vinuesa-García, Antonio Sánchez-Porto, Inmaculada López-Hernández, Jesús Rodríguez‐Baño, the PROBAC REIPI/GEIH-SEIMC/SAEI group
Abstract
Biliary tract infections are frequent, and a significant cause of morbidity and mortality. Bacteremia is common in these infections, particularly in the elderly and patients with cancer. Inappropriate empirical treatment has been associated with increased risk of mortality in bacteremic cholangitis, and the probability of receiving inactive empirical treatment is higher in episodes caused by enterococci. This is because many of the antimicrobial agents recommended in guidelines for biliary tract infections lack activity against these organisms. To the best of our knowledge, this is the first study analyzing the predictive factors for enterococcal BT-BSI and deriving a predictive score.