Sinensetin, a polymethoxyflavone from citrus fruits, ameliorates LPS-induced acute lung injury by suppressing Txnip/NLRP3/Caspase-1/GSDMD signaling-mediated inflammatory responses and pyroptosis
Zaibin Xu, Huiyu Hu, Kongyan Wang, Ziyi Zhou, Xinqian He, Xinan Huang, Yingjie Hu, Jiawen Huang, Zhuohui Luo
Abstract
macrophage M1 polarization experiments. In conclusion, the results revealed that SIN ameliorated the onset and progression of ALI by inhibiting Txnip/NLRP3/Caspase-1/GSDMD signaling-mediated inflammatory responses and pyroptosis. These findings emphasize the significant role of SIN in ameliorating ALI and provide insights into the strategy for exploring the functional effects of foods.
Topics & Concepts
PyroptosisTXNIPChemistryInflammasomePharmacologyInflammationMedicineOxidative stressImmunologyBiochemistryThioredoxinInflammasome and immune disordersPhytochemistry and Biological ActivitiesFlavonoids in Medical Research