Assessment of genome packaging in AAVs using Orbitrap-based charge-detection mass spectrometry
Tobias P. Wörner, Joost Snijder, Olga Friese, Thomas W. Powers, Albert J. R. Heck
Abstract
viral capsids per milliliter. The method quickly assesses the integrity and amount of genome packed AAV particles to support AAV bioprocessing and characterization of this rapidly emerging class of advanced drug therapies.
Topics & Concepts
OrbitrapMass spectrometryChromatographyChemistryAnalytical Chemistry (journal)Virus-based gene therapy researchViral Infections and Immunology ResearchAdvanced biosensing and bioanalysis techniques