The inhibition of YTHDF3/m<sup>6</sup>A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer
Sheng Zhong, Quanwei Guo, Xiaona Chen, Xiaomin Luo, Yufei Long, Tuotuo Chong, Ming Ye, Hui He, Anwei Lu, Keyi Ao, Minuo Yin, Aimin Xu, Xin Li, Yi Hao, Xia Guo
Abstract
A modification resulted in increased expression of FASN and ACC1, leading to both lipolysis of lipid droplets and synthesis of free fatty acid. Ultimately, this promoted fatty acid metabolism and enhanced LN metastasis by activating the LRP6-YAP-VEGF-C axis, which could induce lymphangiogenesis in CCa. Our study highlighted that YTHDF3 can serve as a promising therapeutic target and predictive biomarker for CCa patients with LN metastasis.
Topics & Concepts
LymphangiogenesisDownregulation and upregulationMetastasisCancer researchLipid metabolismCancerAngiogenesisBiologyOncogeneFatty acid metabolismFatty acidMedicineInternal medicineEndocrinologyBiochemistryCell cycleGeneRNA modifications and cancerCancer-related molecular mechanisms researchCancer-related gene regulation