Oxidation-Sensitive Core–Multishell Nanocarriers for the Controlled Delivery of Hydrophobic Drugs
Keerthana Rajes, Karolina Walker, Sabrina Hadam, Fatemeh Zabihi, Jumana Ibrahim-Bacha, Gregor Germer, Piotr Patoka, B. Wassermann, Fiorenza Rancan, E. Rühl, Annika Vogt, Rainer Haag
Abstract
THPP was selectively enhanced in skin under oxidative stress. The number and position of the thioether groups influenced the physicochemical as well as drug delivery properties of the carriers.
Topics & Concepts
NanocarriersChemistryDrug deliveryOxidative stressHydrogen peroxideBiophysicsNile redDrugPhotosensitizerCombinatorial chemistryOrganic chemistryPharmacologyFluorescenceBiochemistryMedicinePhysicsQuantum mechanicsBiologyPhotochromic and Fluorescence ChemistryNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry