Nature-inspired protein mineralization strategies for nanoparticle construction: advancing effective cancer therapy
Yuan Cao, Rui Xu, Yixia Liang, Jiabao Tan, Xiaotang Guo, Junyue Fang, Shibo Wang, Lei Xu
Abstract
. Herein, initially, we analyze the role of protein molecules in biomineralization and comprehensively review the functions, properties, and applications of various common proteins and metal particles. Subsequently, we systematically review and summarize the application directions of nanoparticles synthesized based on protein biomineralization in tumor treatment. Specifically, we discuss their use as efficient drug delivery carriers and role in mediating monotherapy and synergistic therapy using multiple modes. Also, we specifically review the application of nanomedicine constructed through biomimetic mineralization strategies using natural proteins and metal ions in improving the efficiency of tumor immunotherapy.