Tetrahydro-β-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity
Xin Chen, Jiayun Wang, Peng Zhao, Baiyun Dang, Ting Liang, Raphael R. Steimbach, Aubry K. Miller, Jia Liu, Xin Wang, Tongtong Zhang, Xiaofa Luan, Jiadong Hu, Jin‐Ming Gao
Topics & Concepts
ChemistryHDAC6Hydroxamic acidIn vitroDocking (animal)Broad spectrumMelanomaIC50HDAC8Histone deacetylaseCell culturePharmacologyStructure–activity relationshipStereochemistryBiochemistryCancer researchHistoneCombinatorial chemistryBiologyGeneMedicineNursingGeneticsHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisPhytochemical compounds biological activities