Chloroquine to fight COVID-19: A consideration of mechanisms and adverse effects?
Xiping Zhan, Sharon Dowell, Ying Shen, Dexter L. Lee
Abstract
and hyperpolarization-activated cyclic nucleotide-gated channels in cardiac myocytes and neuronal cells. We propose that intracellular calcium homeostasis is an alternative mechanism for CQ/HCQ pharmacology, which should be considered when evaluating the risks and benefits of therapy in these patients and other perspective applications.
Topics & Concepts
ChloroquineHydroxychloroquineRheumatoid arthritisMedicinePharmacologyMechanism (biology)Coronavirus disease 2019 (COVID-19)Mechanism of actionPandemicAdverse effectBioinformaticsImmunologyIntensive care medicineDiseaseMalariaBiologyInternal medicineInfectious disease (medical specialty)EpistemologyBiochemistryIn vitroPhilosophyLong-Term Effects of COVID-19COVID-19 Clinical Research StudiesCalcium signaling and nucleotide metabolism