Regulation of interference-sensitive crossover distribution ensures crossover assurance in <i>Arabidopsis</i>
Xiang Li, Jun Zhang, Jiyue Huang, Jing Xu, Zhiyu Chen, Gregory P. Copenhaver, Yingxiang Wang
Abstract
Significance Meiotic crossovers (COs) are required for accurate chromosome segregation and mix parental genomes to generate genetically diversified gametes. The distribution of COs among chromosomes is not random. In most organisms, at least one CO is formed between each chromosome pair. However, the molecular mechanisms controlling CO distribution are not well understood. Here, we found that Arabidopsis AtFANCD2, AtFANCM, AtFIGL1, and AtRMI1 promote normal distribution of Class I CO to maintain CO assurance in addition to their previously described roles in regulating Class II CO number. These factors, alone or in combination, appear to control ∼50% of the variation between wild-type and random distributions. These discoveries provide genetic insights into understanding of the regulation of CO distribution among chromosomes.