LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men
Christoffer Hagemann, Malene S. Jensen, Stephanie Holm, Lærke S. Gasbjerg, Sarah Byberg, Kirsa Skov‐Jeppesen, Bolette Hartmann, Jens J. Holst, Flemming Dela, Tina Vilsbøll, Mikkel Christensen, Birgitte Holst, Filip K. Knop
Abstract
meal test. In wild-type mice, plasma glucose and food intake are reduced by LEAP2 dosing, but not in GHSR-null mice, pointing to GHSR as a potential mediator of LEAP2's glucoregulatory and appetite-suppressing effects in mice.
Topics & Concepts
GhrelinPostprandialEndocrinologyInternal medicineGrowth hormone secretagogue receptorAppetiteCrossover studyHormoneMealBiologyInsulinMedicinePlaceboAlternative medicinePathologyRegulation of Appetite and ObesityBiochemical Analysis and Sensing TechniquesAdipose Tissue and Metabolism