Ferroptosis in ischemia-reperfusion injury: molecular mechanisms and therapeutic strategies
Yali Wei
Abstract
, GPX4, ACSL4, TfR1, and NCOA4 in the body. This review summarizes the mechanisms, organ-specific manifestations, and current therapeutic strategies of ferroptosis in IRI. It is helpful for the theoretical foundation and potential direction of clinical targeted therapy.
Topics & Concepts
Lipid peroxidationGPX4MedicineHomeostasisReactive oxygen speciesProgrammed cell deathPathogenesisOxidative stressCell biologyPathologicalCell injuryMitochondrionBioinformaticsOxidative damageMechanism (biology)Oxidative phosphorylationIron homeostasisEnergy metabolismImmunologyNeuroscienceLipid metabolismLiver injuryInflammationCause of deathDetoxification (alternative medicine)Cell metabolismHypoxia (environmental)Oxygen metabolismCellTherapeutic approachApoptosisCancer researchEnergy homeostasisPeroxidaseFerroptosis and cancer prognosisTrace Elements in HealthSelenium in Biological Systems