Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis
Yuan Yuan, Yong‐Hwee Eddie Loh, Xia Han, Jifan Feng, Thach‐Vu Ho, Jinzhi He, Junjun Jing, Kimberly Groff, Alan Wu, Yang Chai
Abstract
expression, respectively. The common progenitors undergo further bifurcations to restrict them into osteogenic/odontogenic and chondrogenic/fibroblast lineages. Disruption of a patterning domain leads to specific mandible and tooth defects, validating the binary cell fate restriction process. Different from the compartment model of mandibular morphogenesis, our data redefine heterogeneous cellular domains within the FPA, reveal dynamic cellular movement in time, and describe a sequential series of binary cell fate decision-making process.
Topics & Concepts
MorphogenesisNeural crestFate mappingMovement (music)AnatomyCell fate determinationCranial neural crestBiologyNeuroscienceCell biologyEmbryoStem cellGeneticsPhilosophyProgenitor cellTranscription factorAestheticsGenedental development and anomaliesDevelopmental Biology and Gene RegulationCraniofacial Disorders and Treatments