“VTT”-Domain Proteins VMP1 and TMEM41B Function in Lipid Homeostasis Globally and Locally as ER Scramblases
Karin M. Reinisch, Xiaowei Chen, Thomas J. Melia
Abstract
Recent studies have identified the metazoan ER-resident proteins, TMEM41B and VMP1, and so structurally related VTT-domain proteins, as glycerolipid scramblases.
Topics & Concepts
Domain (mathematical analysis)Function (biology)HomeostasisChemistryCell biologyProtein domainBiologyComputational biologyBiochemistryGeneMathematicsMathematical analysisATP Synthase and ATPases ResearchEndoplasmic Reticulum Stress and DiseaseCellular transport and secretion