Reversible control of biomaterial properties for dynamically tuning cell behavior
Fallon M. Fumasi, Nicholas Stephanopoulos, Julianne L. Holloway
Abstract
In the past decade, significant advances in chemistry and manufacturing have enabled the development of increasingly complex and controllable biomaterials. A key innovation is the design of dynamic biomaterials that allow for user-specified, reversible, temporal control over material properties. In this review, we provide an overview of recent advancements in reversible biomaterials, including control of stiffness, chemistry, ligand presentation, and topography. These systems have wide-ranging applications within biomedical engineering, including in vitro disease models and tissue-engineered scaffolds to guide multistep biological processes.
Topics & Concepts
BiomaterialTissue engineeringNanotechnologyComputer scienceMaterials scienceBiochemical engineeringBiomedical engineeringEngineeringCellular Mechanics and Interactions3D Printing in Biomedical ResearchElectrospun Nanofibers in Biomedical Applications