One-pot hydrothermal synthesis of a magnetic hydroxyapatite nanocomposite for MR imaging and pH-Sensitive drug delivery applications
Mehraneh Kermanian, Mehran Naghibi, Somayeh Sadighian
Abstract
efficacy of the synthesized nanocomposites as a magnetic resonance imaging (MRI) contrast agent was also investigated. Our results showed that IO-HA nanocomposite is non-cytotoxic and hemocompatible as well as a good pH-sensitive drug carrier and a favorable MRI T2 contrast agent. Comparing to the free curcumin, Cur@IO-HA displayed a good cellular uptake. Taking into account the above issues, IO-HA nanocomposite has the most potential for application as a theranostic MRI contrast agent.
Topics & Concepts
BiocompatibilityNanocompositeDrug deliveryNuclear chemistryMRI contrast agentMaterials scienceNanoparticleNanotechnologyMagnetic nanoparticlesChemical engineeringDrug carrierNanorodSuperparamagnetismBromideHydrothermal synthesisHydrothermal circulationChemistryOrganic chemistryMetallurgyMagnetizationEngineeringMagnetic fieldQuantum mechanicsPhysicsBone Tissue Engineering MaterialsNanoparticle-Based Drug DeliveryNanocluster Synthesis and Applications