Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth
I. Caroline Vaaland Holmgard, Aday González-Bakker, Eleonora Poeta, Adrián Puerta, Miguel X. Fernandes, Barbara Monti, José G. Fernández‐Bolaños, José M. Padrón, Óscar López, Emil Lindbäck
Abstract
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro and no neurotoxicity.
Topics & Concepts
CoumarinConjugateNeurotoxicityButyrylcholinesteraseIn vitroChemistryPharmacologyCombinatorial chemistryBiochemistryEnzymeAchéAcetylcholinesteraseMedicineToxicityOrganic chemistryMathematical analysisMathematicsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsNicotinic Acetylcholine Receptors Study