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MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma

Yu Qian, Ana Galán‐Cobo, Irene Guijarro, Minghao Dang, David Molkentine, Alissa Poteete, Fahao Zhang, Qi Wang, Jing Wang, Edwin R. Parra, Apekshya Panda, Jacy Fang, Ferdinandos Skoulidis, Ignacio I. Wistuba, Svena Verma, Taha Merghoub, Jedd D. Wolchok, Kwok‐Kin Wong, Ralph J. DeBerardinis, John D. Minna, Natalie I. Vokes, Catherine B. Meador, Justin F. Gainor, Linghua Wang, Alexandre Reuben, John V. Heymach

2023Cancer Cell178 citationsDOIOpen Access PDF

Topics & Concepts

SecretionAdenocarcinomaImmunityCancer researchLungBiologyChemistryImmune systemImmunologyMedicineInternal medicineEndocrinologyCancerCancer-related molecular mechanisms researchRNA modifications and cancerCancer Immunotherapy and Biomarkers
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma | Litcius