Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans
Neşem P. Özbey, Soudabeh Imanikia, Christel Krueger, Iris Hardege, Julia Morud, Ming Sheng, William R Schafer, Olivia Casanueva, Rebecca C. Taylor
Abstract
activation and extended longevity, and exposure to stress led to splicing and activation of xbp-1 in these neurons. In addition, we found that neuronal xbp-1s modulates feeding behavior and reproduction, dependent upon tyramine synthesis. XBP-1s therefore remodels neuronal signaling to coordinately modulate intestinal physiology and stress-responsive behavior, functioning as a global regulator of organismal responses to stress.
Topics & Concepts
BiologyCell biologyProteostasisSignal transductionTranscription factorCaenorhabditis elegansTyramineCell signalingNeuroscienceBiochemistryGeneGenetics, Aging, and Longevity in Model OrganismsCircadian rhythm and melatoninEndoplasmic Reticulum Stress and Disease