Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs
Niall A. Anderson, Jenni Cryan, Adil Ahmed, Han Dai, Grant A. McGonagle, Christine Rozier, Andrew B. Benowitz
Topics & Concepts
PalbociclibCereblonUbiquitin ligaseCyclin-dependent kinase 6ProteasomeChemistryUbiquitinProtein degradationPharmacologyCyclin-dependent kinaseCell cycleBiochemistryCancerCellBiologyBreast cancerMetastatic breast cancerGeneGeneticsProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments