A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility
Junfan Guo, Wenxia Yu, Min Li, Hongyu Chen, Jie Liu, Xiaowen Xue, Jianxiang Lin, Shisheng Huang, Wenjie Shu, Xingxu Huang, Zhen Liu, Shengqi Wang, Yunbo Qiao
Topics & Concepts
BiologyCytosine deaminaseMitochondrial DNACytosineNuclear DNAGenome editingDNAEffectorMolecular biologyTransactivationCRISPRMitochondrionGeneGeneticsNuclear geneCell biologyTranscription factorGenetic enhancementCRISPR and Genetic EngineeringBacterial Genetics and BiotechnologyRNA and protein synthesis mechanisms