METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer
Lijie Li, Jie Zeng, Sili He, Yanfei Yang, Chen Wang
Abstract
xenograft experiments demonstrated that inhibiting METTL14 reduced the anticancer effects of sorafenib, whereas suppression of FTH1 significantly enhanced sorafenib-induced ferroptosis and increased its anticancer efficacy. METTL14 reduces FTH1 mRNA stability through m6A methylation, thereby enhancing sorafenib-induced ferroptosis, which contributes to suppressing CC progression via the PI3K/Akt signaling pathway.
Topics & Concepts
SorafenibGene knockdownCancer researchMethylationApoptosisChemistryBiologyHepatocellular carcinomaBiochemistryGeneRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research