Impact of the new ultra-high sensitivity mode in a long axial field-of-view PET/CT
Clemens Mingels, Sabine Weidner, Hasan Sari, Dorothee Buesser, Konstantinos Zeimpekis, Kuangyu Shi, Ian Alberts, Axel Rominger
Abstract
Abstract Objective Long axial field-of-view (LAFOV) PET/CT showed improved performance resulting from higher sensitivity. The aim was to quantify the impact of using the full acceptance angle (UHS) in image reconstructions with the Biograph Vision Quadra LAFOV PET/CT (Siemens Healthineers) compared to the limited acceptance angle (high sensitivity mode, HS). Methods 38 oncological patients examined on a LAFOV Biograph Vision Quadra PET/CT were analysed. 15 patients underwent [ 18 F]FDG-PET/CT, 15 patients underwent [ 18 F]PSMA-1007 PET/CT, and 8 patients underwent [ 68 Ga]Ga-DOTA-TOC PET/CT. Signal-to-noise ratio (SNR) and standardised uptake values (SUV mean/max/peak ) were used to compare UHS and HS with different acquisition times. Results The SNR was significantly higher for UHS compared to HS over all acquisition times (SNR UHS/HS [ 18 F]FDG: 1.35 ± 0.02, p < 0.001; [ 18 F]PSMA-1007: 1.25 ± 0.02, p < 0.001; [ 68 Ga]Ga-DOTA-TOC: 1.29 ± 0.02, p < 0.001). Conclusion UHS showed significantly higher SNR opening the possibility of halving short acquisition times. This is of advantage in further reduction of whole-body PET/CT acquisition.