Maternal low protein diet and fetal programming of lean type 2 diabetes
Vidyadharan Alukkal Vipin, Chellakkan S. Blesson, Chandra Yallampalli
Abstract
origins of lean T2D, although other mechanisms might also contribute to the pathology. Observational studies in humans and experiments in animals strongly suggest an association between maternal low protein diet and lean T2D phenotype. In addition, clear sex-specific disease prevalence was observed in different studies. Consequently, more research is essential for the understanding of the etiology and pathophysiology of lean T2D, which might help to develop better disease prevention and treatment strategies. This review examines the role of protein insufficiency in the maternal diet as the central driver of the developmental programming of lean T2D.
Topics & Concepts
MedicineType 2 diabetesPregnancyObesityDiseaseEtiologyDiabetes mellitusGlucose homeostasisBioinformaticsPhysiologyEndocrinologyInsulin resistanceInternal medicineBiologyGeneticsBirth, Development, and HealthGestational Diabetes Research and ManagementDiet and metabolism studies