An Efficient and Versatile Deep Eutectic Solvent-Mediated Green Method for the Synthesis of Functionalized Coumarins
Ishfaq Ahmad Rather, Rashid Ali
Abstract
) in 98% yield within 10 min. On the other front, the same DES at relatively lower reaction temperature (90 °C) was found to provide the bis-coumarins in decent yields (81-97%) within 20-45 min. Moreover, this particular method was found to be quite effective for large-scale coumarin synthesis without noteworthy reduction in the yields of the desired products. Noticeably, in this versatile approach, the DES plays a dual role as solvent as well as catalyst, and it was effectively recycled and reused four times with no significant drop-down in the yield of the product.
Topics & Concepts
Deep eutectic solventYield (engineering)Choline chlorideCoumarinSolventChemistryPhloroglucinolCatalysisOrganic chemistryEutectic systemCombinatorial chemistryMaterials scienceAlloyMetallurgyIonic liquids properties and applicationsChemical Synthesis and ReactionsOxidative Organic Chemistry Reactions