Myocarditis and COVID-19 Mrna Vaccines: A Mechanistic Hypothesis Involving dsRNA
G. Milano, Jocelyn Gal, Anne Creisson, Emmanuel Chamorey
Abstract
While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA is a known inducer of immune-inflammatory reactions. dsRNA present in vaccine nanoparticles may be suspected to be at the origin of the still unexplained cases of myocarditis.
Topics & Concepts
RNA silencingMyocarditisVirologyVaccinationMessenger RNACoronavirus disease 2019 (COVID-19)Immune systemRNAMedicineBiologyImmunologyDiseasePathologyGeneRNA interferenceInternal medicineGeneticsInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchViral Infections and Immunology ResearchRNA Interference and Gene Delivery