Metabolic sinkholes: Histones as methyl repositories

Abstract

S-adenosylmethionine (SAM) functions as the major methyl donor for numerous cellular reactions and processes including DNA, RNA and protein methylation, amino acid metabolism, nucleotide synthesis, neurotransmitter synthesis, and more. SAM's role is facilitated by its readily available methyl group (CH 3 ) for transfer in various methylation reactions catalysed by methyltransferase enzymes

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