Discovery and Control of Succinimide Formation and Accumulation at Aspartic Acid Residues in The Complementarity-Determining Region of a Therapeutic Monoclonal Antibody
Zachary L. VanAernum, Joseph A. Sergi, Monisha Dey, Timothy J. Toner, Bruce Kilgore, Ashley Lay-Fortenbery, Yi Wang, Shengjie Bian, Brent Kochert, Jameson R. Bothe, Xinliu Gao, Douglas D. Richardson, Hillary A. Schuessler
Topics & Concepts
SuccinimideAspartic acidMonoclonal antibodyChemistryComplementarity (molecular biology)Complementarity determining regionAntibodyBiochemistryMonoclonalStereochemistryBiologyImmunologyAmino acidGeneticsProtein purification and stabilityMonoclonal and Polyclonal Antibodies ResearchViral Infectious Diseases and Gene Expression in Insects